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Wetenschappelijke publicaties

Op deze pagina zijn alle wetenschappelijke artikelen te vinden die tot op heden zijn voortgekomen uit het BioClock Consortium.

2026

  • Buddendorf, S. W. J., Broeckx, H.D., van Delft, J., Groot, A.T., Visser, M. E., Burdfield-Steel, E. R. & Spoelstra, K. (2026). Dimming streetlights in urban areas reduces insect attraction but pipistrelle bats forage more in darkness, Biological Conservation, Volume 314,  https://doi.org/10.1016/j.biocon.2025.111638

  • Bijlsma A, van Gilst D, Chaves I, Reiss IKM, Joosten KFM, Kouwenhoven SMP, Vermeulen MJ, Roelants JA. (2026). Chrononutrition: 24-hour variation in macronutrients in very preterm human milk. Early Hum Dev.  https://doi.org/10.1016/j.earlhumdev.2026.106481

2025

  • Visser E, Rus-Oswald OG, van der Does AJW, Gordijn MCM, Marcelis MC, de Kort YAW, Oomen PP, Schlangen LJM, Seetsen T, Simons CJP, Antypa N. (2025). BioClock-optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms. Trials. https://doi.org/10.1186/s13063-025-08984-7

  • Hiemstra FW, González LB, Engelhardt LJ, Hancke L, Pilz LK, Adler AI, Dashti HS, Drouot X, Kitchen GB, Knauert MP, Kramer A, Lipton JO, Luetz A, Maas MB, Pajor NM, Parthasarathy S, Spies C, van Westerloo DJ, Felten M, Klerman EB, Ray DW, Ruben MD, Roenneberg T, Kervezee L. (2025). Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap. Chest.  https://doi.org/10.1016/j.chest.2025.12.010

  • Pape LM, van Straten A, Struijs SY, Karch JD, Spinhoven P, Antypa N; (2025). Caring Universities Consortium. Effects of a Guided Digital Intervention on Sleep and Mental Health Outcomes in University Students – A Randomized Controlled Trial. Sleep. https://doi.org/10.1093/sleep/zsaf357

  • Albalak, G., van Bodegom, D., Thangarajah, P., Giltay, E. J., van Heemst, D., & Noordam, R. (2025). Association between device-based measured physical activity timing and depression risk: A prospective cohort study of UK Biobank participants. BMJ Public Health, 3, e002245. https://doi.org/10.1136/bmjph-2024-002245
  • Buddendorf, S. W. J., Visser, M. E., & Spoelstra, K. (2025). Temperature amplifies the effect of anthropogenic light on foraging common pipistrelle bats. Biology Letters, 21(6), Article 20250049. https://doi.org/10.1098/rsbl.2025.0049 
  • Charvalakis, G. A., Stavenga, D. G., Visser, M. E., Spoelstra, K., & Hut, R. A. (2025). Intensity and colour of artificial light at night affect insect attraction in a taxon‑dependent manner. Insect Conservation and Diversity. Advance online publication. https://doi.org/10.1111/icad.12855 
  • Feng, Q., Albalak, G., van Dijk, K. W., van der Velde, J. H. P. M., Xiao, Q., Noordam, R., & van Heemst, D. (2025). Accelerometer-measured chronoactivity and type 2 diabetes risk: A prospective study in UK Biobank participants. Preventive medicine, 197, 108312. Advance online publication. https://doi.org/10.1016/j.ypmed.2025.108312
  • Kervezee, L., et al. (2025). Development of 24-Hour Rhythms in Cortisol Secretion Across Infancy: A Systematic Review and Meta-Analysis of Individual Participant Data. The Journal of Clinical Endocrinology and Metabolism, 110(2), e515–e524. https://doi.org/10.1210/clinem/dgae590
  • Pape, L. M., Antypa, N., Spinhoven, P., et al. (2025). Open pilot study of a guided digital self‑help intervention targeting sleep and the biological clock in university students using a pre‑test post‑test design. Scientific Reports, 15, Article 21837. https://doi.org/10.1038/s41598‑025‑04891‑8
  • Potts, K. S., Veldkamp, C., Wood, A. C., Michos, E. D., Noordam, R., Huang, T., Redline, S., & Wang, H. (2025). The joint association of diet quality and sleep regularity with incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Nutrients, 17(11), 1750. https://doi.org/10.3390/nu17111750 
  • Shiba, A., Hardonk, M. H., Foppen, E., Kool, T., la Fleur, S. E., Lucassen, P. J., Yi, C.-X., Stenvers, D. J., Mul, J. D., & Kalsbeek, A. (2025). Voluntary running and estrous cycle modulate ΔFOSB in the suprachiasmatic nucleus of the Wistar rat. Journal of Circadian Rhythms, 23(1), 7. https://doi.org/10.5334/jcr.257
  • Shiba, A., Tandari, R., Foppen, E., Yi, C.-X., Mul, J. D., Stenvers, D. J., & Kalsbeek, A. (2025). Combining Time-Restricted Wheel Running and Feeding During the Light Phase Increases Running Intensity Under High-Fat Diet Conditions Without Altering the Total Amount of Daily Running. International Journal of Molecular Sciences, 26(15), 7658. https://doi.org/10.3390/ijms26157658
  • Smit, A. E., Binda, T. R. R., van Heemst, D., Noordam, R., & Winter, E. M. (2025). Self-reported sleep disturbances are associated with osteoporosis: Multivariable-adjusted and Mendelian randomization analyses in UK Biobank. JBMR Plus, 9(7), ziaf085. https://doi.org/10.1093/jbm4/ziaf085
  • van Beurden, A. W., Meijer, J. H., & Rohling, J. H. T. (2025). Incorporating physical activity in a new two-oscillator model of circadian activity in nocturnal and diurnal mammals. Journal of Biological Rhythms, 40(1), 27–35. https://doi.org/10.1177/07487304241303554
  • Vink, K., Kusters, J., & Wallinga, J. (2025). Chrono-optimizing vaccine administration: a systematic review and meta-analysis. Frontiers in public health, 13, 1516523. https://doi.org/10.3389/fpubh.2025.1516523
  • Vitkute K., Borghese F., Hut R.A., Havekes R. & Meerlo P. (2025), Shedding Light
    on Brain Function and Mood: A Role for the Retinoraphe Pathway in Regulating Serotonin, Biological Psychiatry, doi: https://doi.org/10.1016/j.biopsych.2025.06.029.
  • Xiao, Q., Feng, Q., Rutter, M. K., Albalak, G., Wang, H., & Noordam, R. (2025). Associations between the timing of 24 h physical activity and diabetes mellitus: results from a nationally representative sample of the US population. Diabetologia, 68(5), 1005–1015. https://doi.org/10.1007/s00125-025-06368-9

2024

  • Albalak, G., Noordam, R., van der Elst, M., Kervezee, L., Exadaktylos, V., van Bodegom, D., & van Heemst, D. (2024). Older adults exercising ON TIME: Protocol for a randomized controlled cross-over study to assess the effect of physical activity timing on insomnia severity. Trials, 25, 523. https://doi.org/10.1186/s13063-024-08310-7

  • Brouwers, T. M. J., Çobanoğlu, Ü. G., Geers, D., Rietdijk, W. J. R., Gommers, L., Bogers, S., Lammers, G. J., van der Horst, G. T. J., Chaves, I., GeurtsvanKessel, C. H., Koch, B. C. P., de Vries, R. D., van Baarle, D., van der Kuy, H. M., & Lammers-van der Holst, H. M. (2024). The effect of sleep and shift work on the primary immune response to messenger RNA-based COVID-19 vaccination. Journal of Sleep Research, n/a(n/a), e14431. https://doi.org/10.1111/jsr.14431

  • Fawzi, N., Kragten, M., & Bredeweg, B. (2024). Qualitative Reference Model for Learning about Melatonin Regulation. In 37thInternational WorkshoponQualitativeReasoning (pp. 6-13)

  • Hiemstra, F. W., Stenvers, D. J., Kalsbeek, A., de Jonge, E., van Westerloo, D. J., & Kervezee, L. (2024). Daily variation in blood glucose levels during continuous enteral nutrition in patients on the intensive care unit: A retrospective observational study. EBioMedicine, 104, 105169. https://doi.org/10.1016/j.ebiom.2024.105169
  • Lammers-van Der Holst, H. M., Qadri, S., Murphy, A., Ronda, J. M., Zhang, Y., Barger, L. K., & Duffy, J. F. (2024). Evaluation of sleep strategies between night shifts in actual shift workers. Sleep Health, 10(1), S108–S111. https://doi.org/10.1016/j.sleh.2023.08.025
  • Lamprou, E., Kivelä, L. M. M., Rohling, J. H. T., Meijer, J. H., van der Does, W., & Antypa, N. (2024). Chronotype, sleep quality, depression and pre-sleep rumination: A diary and actigraphy study. European Journal of Neuroscience, 60(11), 6593–6604. https://doi.org/10.1111/ejn.16551
  • Noordam, R., Ao, L., Stroo, J. F., Willems van Dijk, K., & van Heemst, D. (2024). No evidence linking sleep traits with white blood cell counts: Multivariable-adjusted and Mendelian randomization analyses. European Journal of Clinical Investigation, 54, e14189. https://doi.org/10.1111/eci.14189 
  • Pape, L. M., Jonker, S., Kivelä, L. M. M., van Straten, A., & Antypa, N. (2024). Effectiveness of a multi-component sleep-mood group intervention on improving insomnia in university students – a pilot randomized controlled trial. BMC Psychology, 12(1), 626. https://doi.org/10.1186/s40359-024-02057-1
  • Pape, L. M., van Straten, A., Struijs, S. Y., Spinhoven, P., & Antypa, N. (2024). Effectiveness of a guided digital self-help intervention to improve sleep and the biological clock in university students – Study protocol for a randomized controlled trial. Internet Interventions, 37, 100763. https://doi.org/10.1016/j.invent.2024.100763
  • Rhee, M. van der, Oosterman, J. E., Wopereis, S., Horst, G. T. J. van der, Chaves, I., Dollé, M. E. T., Burdorf, A., Kerkhof, L. W. M. van, & Holst, H. M. L.-V. der. (2024). Personalized sleep and nutritional strategies to combat adverse effects of night shift work: A controlled intervention protocol. BMC Public Health, 24(1). https://doi.org/10.1186/s12889-024-20022-w

  • Shiba, A., De Goede, P., Tandari, R., Foppen, E., Korpel, N. L., Coopmans, T. V., Hellings, T. P., Jansen, M. W., Ruitenberg, A., Ritsema, W. I. G. R., Yi, C.-X., Mul, J. D., Stenvers, D. J., & Kalsbeek, A. (2024). Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats. Neurobiology of Sleep and Circadian Rhythms, 17, 100106. https://doi.org/10.1016/j.nbscr.2024.100106

  • Van Doorn, G. S., Schepers, J., Hut, R. A., & Groot, A. T. (2024). Sex-specific expression of circadian rhythms enables allochronic speciation. Evolution Letters, qrae049. https://doi.org/10.1093/evlett/qrae049

2023

  • Albalak, G., Stijntjes, M., van Bodegom, D., Jukema, J. W., Atsma, D. E., van Heemst, D., & Noordam, R. (2023). Setting your clock: Associations between timing of objective physical activity and cardiovascular disease risk in the general population. European Journal of Preventive Cardiology, 30(3), 232–240. https://doi.org/10.1093/eurjpc/zwac239
  • Van Gilst, D., Puchkina, A. V., Roelants, J. A., Kervezee, L., Dudink, J., Reiss, I. K. M., Van Der Horst, G. T. J., Vermeulen, M. J., & Chaves, I. (2023). Effects of the neonatal intensive care environment on circadian health and development of preterm infants. Frontiers in Physiology, 14, 1243162. https://doi.org/10.3389/fphys.2023.1243162
  • Wackers, P., Dollé, M. E. T., van Oostrom, C. T. M., & van Kerkhof, L. W. M. (2023). Exploration of genome-wide DNA methylation profiles in night shift workers. Epigenetics, 18(1), 2152637. https://doi.org/10.1080/15592294.2022.2152637

2022

  • Albalak, G., Stijntjes, M., Wijsman, C. A., Slagboom, P. E., van der Ouderaa, F. J., Mooijaart, S. P., van Heemst, D., & Noordam, R. (2022). Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: A cross-sectional and prospective analysis. International Journal of Obesity (2005), 46(3), 515–522. https://doi.org/10.1038/s41366-021-01018-7
  • Bizzarri, D., Dollé, M. E. T., Loef, B., van den Akker, E. B., & van Kerkhof, L. W. M. (2022). GlycA, a Biomarker of Low-Grade Inflammation, Is Increased in Male Night Shift Workers. Metabolites, 12(12), Article 12. https://doi.org/10.3390/metabo12121172
  • Streng, A. A., Loef, B., Dollé, M. E. T., van der Horst, G. T. J., Chaves, I., Proper, K. I., & van Kerkhof, L. W. M. (2022). Night shift work characteristics are associated with several elevated metabolic risk factors and immune cell counts in a cross-sectional study. Scientific Reports, 12(1), 2022. https://doi.org/10.1038/s41598-022-06122-w

  • Timmer, R., Bogaardt, L., Brummelhuis, W. J., van Oostrom, C. T., van Kerkhof, L. W. M., Wong, A., de Valk, H. W., Ocké, M. C., van der Maaden, T., & Dollé, M. E. T. (2022). A randomized crossover trial assessing time of day snack consumption and resulting postprandial glycemic response in a real-life setting among healthy adults. Chronobiology International, 39(10), 1329–1339. https://doi.org/10.1080/07420528.2022.2105230

2021

  • Caliandro, R., Streng, A. A., van Kerkhof, L. W. M., van der Horst, G. T. J., & Chaves, I. (2021). Social Jetlag and Related Risks for Human Health: A Timely Review. Nutrients, 13(12), Article 12. https://doi.org/10.3390/nu13124543
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The BioClock Consortium is funded by the NWA-ORC programme of the Dutch Research Council (NWO; project number 1292.19.077).