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Wheel running in the wild on BBC Winterwatch

BBC Winterwatch recently showcased a unique study led by Prof. Joke Meijer, head of the BioClock Consortium. The research from 2014 revealed that wild mice — and even other small animals — voluntarily use running wheels placed in their natural environment. These findings challenge the idea that wheel running is merely a behavior caused by captivity and instead reveal it as a natural, self‑motivated activity. On the program, the Winterwatch team even recreated the scientific...

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The clock starts ticking early: circadian variation in preterm breastmilk

Human breast milk is surprisingly adaptive, consistently changing to best meet the baby’s needs. Even the time of day has been known to affect its composition. But what happens when a baby is born very prematurely?  A new study by BioClock researchers Demy van Gilst  and Inês Chaves aimed to find out if 24-hour variations are already present in breastmilk following a very premature birth. Researchers collected around 15 milk samples over 72 consecutive hours,...

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New publication: circadian biology in the Intensive Care Unit

Critically ill patients often experience severe disruption of their sleep cycles and circadian rhythm during their stay in the Intensive Care Unit (ICU). Constant artificial lighting, continuous nutritional intake, and 24/7 medical procedures interfere with the natural rhythms that normally help regulate our internal clock. Research shows that circadian rhythms play a crucial role in physiological regulation, recovery, and overall health, raising an important question: how can we...

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BioClock in the news: The future of night work?

Working night shifts can be demanding, as many night shift workers will recognize. What makes this work so challenging, and how can we improve this?  In a recent article, popular Dutch newspaper De Volkskrant spoke with several BioClock researchers about the effects of night work and possible solutions. Nightshifts and the biological clockThe negative effects of night work are closely related to the biological clock. Normally, it runs in sync with the 24-hour day-night...

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Looking Back: BioClock at Lowlands Science

As widely shared on our social media channels, the BioClock team was present at Lowlands Science 2025 last weekend (16–18 August), where we introduced festival visitors to the fascinating world of the biological clock. The initiative was led by Maaike van der Rhee, Demy van Gilst, Ward Vleeshouwers, and Gali Albalak. Under the motto “Too tired to function? Let’s find out!” our PhD candidates explored the question: how does sleep deprivation affect reaction time, alertness, and even...

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Morning activity lowers depression risk, evening activity increases it

New study highlights the importance of timing in physical activity Research by BioClock scientist Gali Albalak (Leiden University Medical Center) shows that not only how much we move, but also when we move can influence our mental health. The results indicate that people who are primarily active in the morning have a significantly lower risk of depression, whereas nighttime activity is associated with a higher risk. Largest study to date Using data from the UK Biobank, the...

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New pilot study: Digital intervention for better sleep and mental wellbeing in students

Biological clock & Student wellbeing Sleep problems are increasingly common among university students and are strongly linked to mood and anxiety disorders. An irregular day–night rhythm – caused by late bedtimes and social jetlag – worsens these complaints. What was studied? BioClock researcher Laura Pape (Leiden University) and her colleagues developed the digital self-help intervention ‘i-Sleep & BioClock’. This five-week program combines the proven...

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